Sains Malaysiana 53(2)(2024): 369-381
http://doi.org/10.17576/jsm-2024-5302-11
Anti-Angiogenic Effect of Polygonum Species: A Comprehensive Review of Literature
(Kesan Anti-Angiogenik Spesies Polygonum: Kajian Komprehensif Kepustakaan)
NAJLA’ SHAKIRAH AB HALIM1, SHERIL JUNE
ANKASHA1, ASLAH NABILAH ABDULL SUKOR1, NUR NAJMI MOHAMAD
ANUAR2, NORHAZLINA ABDUL WAHAB1, SHAHIDEE ZAINAL ABIDIN3,
AZIZAH UGUSMAN1 & ADILA A HAMID1,*
1Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala
Lumpur, Malaysia
2Programme of Biomedical Science, Centre for Toxicology and Health Risk
Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
3Faculty of Science and Marine Environment, Universiti Malaysia Terengganu, 21300 Kuala Terengganu, Terengganu, Malaysia
Diserahkan: 13 September 2023/Diterima: 6 Februari 2024
Abstract
Angiogenesis is a physiological, tightly regulated
process which is characterized by the development of new blood vessels.
Compounds with the potential to control angiogenesis would be highly valuable
as therapeutics, as an imbalance in angiogenesis may lead to several
pathological disorders, including cancer, retinopathy, and arthritis. In this
study, the anti-angiogenic effect of Polygonum sp. has been comprehensively reviewed and this
plant also has been known to possess other medicinal benefits such as antioxidative, anti-inflammatory, anti-proliferative, and
anti-tumor agents. Hence, this study systematically identified the evidence
reporting the anti-angiogenic effects of Polygonum sp. Four electronic
databases, namely PubMed, Ovid MEDLINE, Scopus and Web of Science were searched
for relevant articles. Based on the pre-set eligibility criteria, 50 relevant
articles were identified, and ten qualified articles were selected and
reviewed. It was demonstrated that four
namely P. cuspidatum, P. barbatum, P. hydropiper, and P. perfoliatum showed anti-angiogenic activities mainly through inhibition of the vascular
endothelial growth factor-signaling pathways. Therefore, these species Polygonum
have the potential to be developed as natural anti-angiogenic agents for
prevention and treatment of various diseases related to pathological
angiogenesis.
Keywords:
Angiogenesis; anti-angiogenesis; Polygonum genus; vascular endothelial growth factor
Abstrak
Angiogenesis adalah proses fisiologi yang dikawal ketat yang dicirikan oleh perkembangan saluran darah baharu. Sebatian yang berpotensi untuk mengawal angiogenesis akan sangat berharga sebagai terapeutik, kerana ketidakseimbangan dalam angiogenesis boleh membawa kepada beberapa gangguan patologi, termasuk kanser, retinopati dan arthritis. Dalam kajian ini, kesan anti-angiogenik spesies Polygonum sp. telah dikaji secara menyeluruh dan tumbuhan ini juga telah diketahui mempunyai manfaat perubatan lain seperti antioksidan, anti-radang, agen anti-proliferatif dan anti-tumor. Walau bagaimanapun, kesan anti-angiogenik Polygonum sp. masih belum diulas. Oleh itu, kajian ini dilakukan secara sistematik untuk mengenal pasti bukti yang melaporkan kesan anti-angiogenik oleh Polygonum sp. Empat pangkalan data elektronik, iaitu PubMed, Ovid
MEDLINE, Scopus dan Web of Science digunakan bagi pencarian artikel yang berkaitan. Berdasarkan kriteria relevan yang telah ditetapkan, terdapat 50 artikel yang berkaitan telah dikenal pasti dan hanya sepuluh artikel yang layak telah dipilih dan diulas. Hasil kajian menunjukkan bahawa terdapat empatiaitu P. cuspidatum, P. barbatum, P. hidropiper dan P. perfoliatum menunjukkan aktiviti anti-angiogenik terutamanya melalui perencatan laluan isyarat faktor pertumbuhan endotelium vaskular. Oleh itu, spesies Polygonum mempunyai potensi untuk dibangunkan sebagai agen anti-angiogenik semula jadi dalam pencegahan dan rawatan pelbagai penyakit yang berkaitan dengan patologi angiogenesis.
Kata kunci:
Angiogenesis; anti-angiogenesis; faktor pertumbuhan endotelium vaskular;
genus Polygonum
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*Pengarang
untuk surat-menyurat; email: adilahamid@ppukm.ukm.edu.my
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